ABSTRACT
Exosomes are membrane vesicles secreted by various cells containing unique proteins and miRNA from secretory cells.They can reflect the physiological and pathological state of secretory cells,and play an important role in cell-to-cell communica?tion.In recent years,the exosomes have become the focus of research,which brings hope for diseases that can not be treated effective?ly.This review aims to summarize the extraction methods,biological markers of diabetic nephropathy(DN)and the potential of exo?somes as drug carriers,hoping to bring new ideas for future studies on the occurrence and development mechanisms as well as the treat?ment of DN.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the anti-aging effect of aqueous extract of Hedysarum austrosibiricum cultivated in Xin-jiang.</p><p><b>METHOD</b>Subacute aging model in mice was established by D-galactose (D-gal) and activities of SOD and GSH-PX, contents of MDA in brain and liver tissues, activities of MAO in brain tissue and immune indexes were determined.</p><p><b>RESULT</b>Aqueous extract of H. austrosibiricum Xinjiang markedly increased the activities of SOD and GSH-PX, significantly decreased contents of MDA in brain and liver tissues. MAO activities in brain tissue were also decreased. It also elevated the spleen and thymus indexes.</p><p><b>CONCLUSION</b>Aqueous extract of H. austrosibiricum might have anti-aging effect, which is implemented by eliminating oxyen free radicals, rising activities</p>